Immunosuppressed Mutation! An HIV+ woman had COVID for 216 days. The virus mutated at least 30 times inside her

Yahoo News:

  • A woman living with HIV was found to carry the novel coronavirus for seven months, a new study sai
  • Scientist detected 32 mutations to the virus, including some seen in variants of concern
  • It suggests that HIV could contribute to variant evolution, but probably in exceptional cases

A 36-year-old woman with advanced HIV carried the novel coronavirus for 216 days, during which the virus accumulated more than 30 mutations, a new study has found.

The case report, which has not been peer-reviewed, was published as a preprint on medRxiv on Thursday. The woman, who has not been named, was identified as a 36-year-old living in South Africa.

The coronaviruses gathered 13 mutations to the spike protein, which is known to help the virus escape the immune response, and 19 other mutations that could change the behavior of the virus. It is not clear whether the mutations she carried were passed on to others, the Los Angeles Times reported.

Some of these mutations have been seen in variants of concern, such as:

  • The E484K mutation, which is part of the Alpha variant (B.1.1.7, which was first seen in the UK).
  • The N510Y mutation, which is part of the Beta variant (B.1.351, which was first seen in South Africa).

If more such cases are found, it raises the prospect that HIV infection could be a source of new variants simply because the patients could carry the virus for longer, Tulio de Oliveira, a geneticist at the University of KwaZulu-Natal in Durban and the study’s author, told the LA Times.

But it is probably the exception rather than the rule for people living with HIV, because prolonged infection requires severe immunocompromise, Dr. Juan Ambrosini, an associate professor of infectious diseases at the University of Barcelona, told Insider. Indeed, the woman in the case study was immunosuppressed.

The findings are important for the control of COVID-19 because these patients could be a continuous source of transmission and evolution of the virus, Ambrosini said.

Immunosuppressed patients could carry the coronavirus longer than others

This case could easily have gone unnoticed, de Oliveira told the LA Times.

This was because after the woman was treated in the hospital for her initial symptoms, she displayed only mild symptoms of COVID-19, even though she was still carrying the coronavirus, de Oliveira said.

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